The PC version of The Amazing Spider-Man has numerous technical problems beyond just save files. The dedicated modding community has created a comprehensive fix that solves many of them, including stability issues that can lead to save corruption.
If you aren't sure where to start, this applies to almost every version: amazing spider man save file damaged
If this happens across multiple games, your PC SSD or console hard drive might be failing. Run a diagnostic check. The PC version of The Amazing Spider-Man has
Periodically copy your Documents\Activision\The Amazing Spider-Man\Save folder to a secure location (e.g., a Desktop folder or USB drive). amazing spider man save file damaged
A simple reboot can clear temporary cache errors.
These versions often use different emulators and store saves in custom folders. Some common paths include: