Cap your framerate to using your GPU control panel (NVIDIA Control Panel or AMD Software) to normalize CPU frame pacing.
If your CPU is over 10-12 years old, it may lack basic AVX support entirely (not just AVX2). The patch allows for non-AVX2 CPUs, but some minimum functional requirements remain. uncharted 4 avx2 fix
Under the tab, ensure your game is set to "Always keep this game updated." Cap your framerate to using your GPU control
Under the tab, ensure the game is set to "Always keep this game updated." involving temporary community workarounds and
The journey to a fix was a multi-step process, involving temporary community workarounds and, eventually, an official solution from the developers.