If you love the novelty of the dual-screen map layout and own a modded New 3DS, installing the CIA file is highly recommended for casual, on-the-go runs. However, if you are looking for the definitive, complete Isaac experience with thousands of items and stable performance, you are better off playing the game on PC, Steam Deck, or Nintendo Switch. If you need help setting up your files, let me know:
The standard raw ROM format, primarily used for PC emulation or with flashcarts like the Gateway 3DS. the binding of isaac rebirth rom 3ds