The series explores their relationship as they navigate their feelings for each other, along with their interactions with a group of supporting characters. Onodera had expected rejection and was prepared to deal with the aftermath of her confession. Instead, she finds herself transitioning into a relationship.

Whether you're a seasoned anime fan or just discovering the series, "Anehame Ore no Hatsukoi ga Jisshi na Wake ga Na 2021" is definitely worth checking out. With its enduring popularity and loyal fan base, it's clear that this anime will continue to be a beloved favorite for years to come.

: The story follows Akira Sakagami, whose attempts to ask out a classmate are disrupted by his older sister, Rio. After Rio catches him in a compromising situation, the two begin an incestuous relationship.